Many games use SPACE for jumping. It can also come in handy if your game alows ability for side jumping like in Tomb Rider.
Also if your game controls are Keyboard + Mouse then I asume that most users would rather have A and D for strafing left and right instead for turing (just like in FPS). You do turning with mouse.
As for interaction many games use either E or F, some even Q.

But best way is to alow player to reasign controls on its own.