I haven't actually gotten around to installing the Skype module for Trillian, so I can't tell you exactly how it integrates the apps together. I just saw it on the page the last time I updated.
Looking at Miranda though, it appears to support more IM protocols then Trillian does at current. Interesting little program, and I may have to take a look at it as well.
Anyone tried building a module for it (Miranda) yet?
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