I haven't actually gotten around to installing the Skype module for Trillian, so I can't tell you exactly how it integrates the apps together. I just saw it on the page the last time I updated.

Looking at Miranda though, it appears to support more IM protocols then Trillian does at current. Interesting little program, and I may have to take a look at it as well.

Anyone tried building a module for it (Miranda) yet?