I tried the game in windowed mode and not in 16:10 fullscreen. But after looking at it again it might be more of a problem with an irritating cursor. In artillery mode your cursor looks like a steering wheel and from it's look the cursor's center should be in the center of the texture but somehow that's not the case so the buttons feel like being offset. Dunno if it's the cursor or a problem with the UI, but maybe dump that cursor for a cursor where the user is actually able to tell where the hit point is.